1998년에 발매되었던 "Best of 1980-1990"의 후속편이라 할 수 있는 본작은 90년부터 2000년까지 U2의 히스토리가 담겨져 있다. 91년 "Achtung baby"에서부터 93년 "Zooropa", 97년 "Pop" 그리고 2000년 "All that you can't leave behind"까지 4장의 음반에서 건져올린 주옥같은 히트곡들과 영화 삽입곡, 그리고 "Electrical Storm", "the Hands that built America" 2 곡의 신곡까지 U2의 제 2막을 정리하고 있다.
CD 1 (The Best Of)
01 Even Better Than The Real Thing
02 Mysterious Ways
03 Beautiful Day
04 Electrical Storm (William Orbit Mix) - New Song
05 One
06 Miss Sarajevo
07 Stay (Faraway, So Close)
08 Stuck In A Moment You Can't Get Out Of
09 Gone (New Mix)
10 Until The End Of The World
11 The Hands That Built America (Theme From 'gangs Of New York') - New Song
12 Discotheque (New Mix)
13 Hold Me, Thrill Me, Kiss Me, Kill Me
14 Staring At The Sun (New Mix)
15 Numb (New Mix)
16 The First Time
CD 2 (The B-Sides)
01 Lady With The Spinning Head (Extended Dance Mix)
02 Dirty Day (Junk Day Mix)
03 Summer Rain
04 Electrical Storm - New Song
05 North And South Of The River
06 Your Blue Room
07 Happiness Is A Warm Gun (The Gun Mix)
08 Salome (Zooromancer Remix)
09 Even Better Than The Real Thing (The Perfecto Mix)
10 Numb (Gimme Some More Dignity Mix)
11 Mysterious Ways (Solar Plexus Club Mix)
12 If God Will Send His Angels (Big Yam Mix)
13 Lemon (Jeep Mix)
14 Discotheque (Hexidecimal Mix)
DVD
01 The History Mix
02 U2 Best of 1990-2000 DVD Trailer
03 Please - Live Mural Cut
04 Beautiful Day - Eze Version